Lappaconitine Hydrobromide

Lappaconitine Hydrobromide(LA) yog ib hom diterpenoid alkaloid, labaconitine, uas yog muab rho tawm thiab cais tawm ntawm aconitum ntawm ranunculus tsev neeg. Nws yog thawj zaug uas tsis yog tshuaj analgesic rau hauv nruab nrab paj hlwb hauv Suav teb. Nws muaj cov teebmeem ntawm analgesia, antipyretic, detumescence thiab tshuaj loog hauv zos, thiab muaj cov yam ntxwv ntawm kev tsis quav ntsej thiab tsis tshua muaj kev phiv. Nws cov nyhuv analgesic muaj zog dua indomethacin thiab tsis muaj zog dua li morphine. Tam sim no, nws muaj zog analgesic thiab immunomodulatory teebmeem yog tsuas yog siv nyob rau hauv kev kuaj mob thiab kev kho mob kev ua ub no ntawm ntau yam tshwj xeeb, thiab nws yog dav siv nyob rau hauv lub lig analgesia thiab perioperative analgesia ntawm cancer.

Lappaconitine yog ib yam khoom nrov ntawm KINTAI. Tom qab ib xyoo caum ntawm kev tshawb fawb thiab kev loj hlob, KINTAI tau ua tiav kev kov yeej ntau yam teeb meem kev lag luam, ua tiav qhov tshwj xeeb purity hauv txhua pawg. Peb tsis tu ncua ua raws li cov qauv nruj nruj thiab tswj hwm tus neeg siv khoom-centric mus kom ze, kom ntseeg tau tias txhua yam khoom ua tau raws li cov qauv tshuaj nruj nruj. Peb muab cov tuam txhab tshuaj thoob ntiaj teb nrog cov txiaj ntsig zoo thiab muaj kev nyab xeeb botanical intermediates. Raws li ib tug neeg muab kev ntseeg siab ntawm botanical active cov khoom xyaw, peb tuav peb txoj hauj lwm nyob rau hauv botanical extraction technology thiab tam sim no yog tus loj tshaj plaws manufacturers ntawm 96%Lappaconitine nyob rau hauv Suav teb.Thov xav tias dawb rau hu rau peb ntawm health@kintaibio.com.

1. Mob plab

Laptopaconitine, kuv lub teb chaws thawj zaug uas tsis yog tshuaj tua kab mob, yog siv los kho ntau yam mob me mus rau nruab nrab, xws li mob qog noj ntshav, mob tom qab phais, thiab sciatica. Clinically, lappaconitine's analgesic efficacy yog xya npaug ntawm aminopyrine, thiab nws tau pom tias muaj kev pab cuam rau cov hniav, trigeminal neuralgia, herpes zoster mob, thiab mob tom qab phais.

2. Anti-inflammatory

Laptopaconitine muaj cov tshuaj tiv thaiv kab mob nruab nrab thiab feem ntau siv hauv cov tshuaj pej xeem los kho cov mob xws li lupus erythematosus, rheumatism, thiab mob caj dab rheumatoid. Laptopaconitine tuaj yeem cuam tshuam tsis muaj kev tsim tawm los ntawm inhibiting NF-κB txoj hauv kev thiab mitogen-activated protein kinase (MAPK) txoj kev taw qhia, yog li txo qis kev qhia ntawm cov kab mob inflammatory (TNF-α, IL-1β, IL-6) thiab chemokines (KC, MCP-1, MIP-1α), ua tiav cov teebmeem tiv thaiv.

3. Antiarrhythmic

Laptopaconitine's antiarrhythmic effect yog ib qho tshwj xeeb ntawm lappaconitine. Lappaconitine belongs rau Class Ic antiarrhythmic natural product class. Kev ua haujlwm antiarrhythmic ntawm nws cov derivatives yog nyob ntawm halogen ntawm C-5 'txoj hauj lwm ntawm pawg aromatic. Qhov kev txiav txim ntawm halogen hloov pauv cuam tshuam rau kev ua haujlwm lom neeg yog: Br > I > Cl. Lappaconitine hydrobromide yog qhov muaj zog tshaj plaws antiarrhythmic derivative.

4. Tshuaj tiv thaiv qog

Lappaconitine sulfate tuaj yeem thaiv A549 hlwb hauv G0 / G1 theem ntawm phosphoinositide 3-kinase / protein kinase B (PI3K / protein kinase B, PKB lossis AKT) qhia txoj hauv kev, ua rau apoptosis, thiab inhibit cell viability thiab proliferation. PI3K / AKT txoj kev taw qhia ua lub luag haujlwm tseem ceeb hauv kev muaj sia nyob ntawm tes, kev loj hlob, thiab kev loj hlob.

5. Cov tshuaj tiv thaiv kab mob vwm

Lappaconitine's inhibition ntawm sodium tam sim no yog siv-nyob thiab tsis hloov qhov voltage-dependence ntawm sodium tam sim no activation thiab inactivation. Lappaconitine xaiv txo lub sijhawm ntawm cov kab mob epileptiform tawm thiab tawg hauv cov neurons vim yog bicuculline, aconitine, lossis Mg2 +-dawb sab nraud tshuaj. Qhov no qhia tau hais tias cov tshuaj tiv thaiv kab mob ntawm lappaconitine tuaj yeem kho los ntawm inhibiting axonal conductance thiab txo cov sodium tam sim no.

1. Kev tsis pom zoo

Qee lub sij hawm, kiv taub hau, palpitations, urticaria, hauv siab nruj, thiab ua xua pob liab liab tuaj yeem tshwm sim, feem ntau daws nws tus kheej.

Kev txhaj tshuaj tuaj yeem ua rau khaus hauv zos.

2. Contraindications thiab ceev faj

Cov khoom no yog contraindicated nyob rau hauv cov neeg mob ua xua.

Siv ceev faj rau cov neeg mob uas mob siab lossis lub raum tsis txaus.

Kev nyab xeeb ntawm cov tshuaj no hauv cov poj niam cev xeeb tub thiab lactating tsis paub; kev siv yuav tsum tau ua tib zoo ntsuas qhov kev pheej hmoo.

Siv ceev faj rau cov neeg mob plawv.

3. Kev Sib Tham Tshuaj

Kev siv ua ke nrog rau lwm yam hauv nruab nrab lub paj hlwb kev nyuaj siab (xws li sedatives thiab hypnotics) tuaj yeem txhim kho kev nyuaj siab.

Kev siv ua ke nrog lwm cov tshuaj yog pom zoo nyob rau hauv tus kws kho mob saib xyuas.

4. Cov Lus Qhia Tshwj Xeeb

Kev pib qeeb qeeb: piv rau cov tshuaj opioids sai sai xws li morphine, Lappaconitine Hydrobromide yuav siv sijhawm li 30 feeb kom tau txais txiaj ntsig tom qab txhaj tshuaj, ua rau nws tsis tsim nyog rau cov xwm txheej hnyav uas yuav tsum tau ua kom muaj tshuaj loog tam sim.

Kev tsim cov lappaconitine feem ntau yog ua raws li cov ntawv sib txawv kom tau raws li kev xav tau ntawm kev kho mob sib txawv. Cov hauv qab no yog nws cov ntawv loj npaum li cas thiab cov qauv tsim:

1. Txhaj tshuaj

Qhov no yog cov feem ntau classic thiab ntau npaum li cas daim ntawv, siv rau mob, mob nruab nrab mus rau hnyav.

Mis:

• Cov khoom xyaw nquag: lappaconitine hydrobromide
• Solvent: Dej rau kev txhaj tshuaj
• pH adjuster: Dilute hydrochloric acid los yog sodium hydroxide tov yog feem ntau siv los kho cov pH mus rau qhov tsim nyog ntau yam (feem ntau 4.0-6.0) los xyuas kom meej cov tshuaj stability thiab txo qhov khaus thaum txhaj tshuaj.
• Muaj peev xwm excipients: Antioxidants (xws li sodium bisulfite) qee zaum ntxiv los txhim kho kev ruaj ntseg.
• Common zog: 4mg / 2ml, 8mg / 2ml, thiab lwm yam.
• Txoj kev ntawm kev tswj hwm: kev txhaj tshuaj intramuscular lossis intravenous infusion.

2. ntsiav tshuaj / ntsiav tshuaj

Qhov no yog siv rau kev saib xyuas kev kho mob ntev, mob tsis tu ncua thiab yooj yim rau kev tswj hwm.

Mis:

• Cov khoom xyaw nquag: lappaconitine hydrobromide
• Bulker: Xws li hmoov txhuv nplej siab, lactose, thiab microcrystalline cellulose, siv los ua kom cov ntsiav tshuaj hnyav. Binders, xws li polyvinylpyrrolidone (PVP) thiab starch slurry, yog siv los khi cov hmoov.
• Disintegrants, xws li cross-linked sodium carboxymethyl cellulose thiab low-sexchanged hydroxypropyl cellulose, txhawb cov ntsiav tshuaj disintegration hauv plab hnyuv.
• Lubricants, xws li magnesium stearate thiab talc, pab cov ntsiav tshuaj compression.
• Common zog: 5 mg / ntsiav tshuaj.

3. Patches (Transdermal Drug Delivery System)

Daim ntawv tshuaj noj tshiab no muab kev noj qab haus huv, ruaj khov thiab tshwj xeeb tshaj yog haum rau cov neeg mob uas mob ntev uas yuav tsum tau noj tshuaj mus ntev (xws li mob qog noj ntshav). Nws zam cov teebmeem thawj zaug dhau los ntawm kab mob siab thiab kev mob plab hnyuv.

Formulation:

• Cov khoom xyaw nquag: Lappaconitine hydrobromide
• Cov nplaum nplaum nplaum, xws li polyacrylates, silicones, los yog polyisobutylenes, ua kom lub thaj ua raws li daim tawv nqaij thiab ua ib qho chaw cia tshuaj thiab tso tsheb.
• Penetration enhancers, xws li aminoketone thiab oleic acid, pab cov tshuaj nkag mus rau stratum corneum.
• Rov qab txheej: Ib zaj duab xis dej-impermeable uas tiv thaiv cov tshuaj evaporation thiab lwm yam kab mob. Anti-stick txheej: Ib txheej tiv thaiv yuav tsum tau muab tshem tawm ua ntej siv.
• Cov txiaj ntsig zoo: Cov tshuaj ntshav siab ruaj khov, cov nyhuv ntev ntev (ntev ntev dua 24 teev), siv tau yooj yim, thiab ua raws li tus neeg mob zoo.

Q1: Dab tsi yog lappaconitine hydrobromide siv rau?

A1: Lappaconitine hydrobromide tau siv dav hauv kev tshawb fawb tsom rau Kev Tswj Kev Mob.

Q2: Koj tus MOQ yog dab tsi?

A2: Peb MOQ yog hloov tau, thov hu rau peb kom tau txais cov ntaub ntawv ntau ntxiv.